However, when this authentication fails, Outlook cannot connect to the Exchange server mailbox and displays the following or similar error message.Ĭannot start Microsoft Outlook. Although Outlook OST file allows users to work even when the system is offline, it needs to authenticate the user profile by matching the MAPIEntryID GUID key with the server mailbox at least once to allow access to OST and Outlook profile. This OST file is encrypted with a unique MAPIEntryID GUID key, which is stored in the registry of your local system and Exchange server. Outlook, when configured with Exchange server profile in Cached Exchange Mode, creates an OST or Offline Folder file. In this guide, we’ve mentioned the reasons behind the error and the solutions to fix the 'Outlook cannot connect to server' error. The error occurs when authentication between Outlook and Exchange server fails due to corrupt profile, damaged or inaccessible OST file, synchronization issues, etc. Outlook may fail to connect to the Exchange server due to several reasons.
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